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";s:4:"text";s:24993:"), 8 g of sodium, and 500 g of orthosilicic acid-2-ethoxyethanol previously obtained from the transesterification of orthosilicic acid tetramethyl ester with 2-ethoxyethanol were charged into the same apparatus as in Example 1. en The formulations comprise a mixture of cobra venom and orthosilicic acid and an acceptable excipient. patents-wipo. The petitioner also provided microbiological specifications. Under a vacuum of 0.1 Torr, 1085 g of orthosilicic acid tetra-2-methoxyethyl ester was obtained at 145° C. in a purity of 99.5%. THE HYDROLYSIS OF ETHYL ORTHOSILICATE AND PREPARATION OF SILICIC ACID GELS FROM IT Introduction Ethyl orthosilicate, (C2H50)4Si,, the ester of orthosilicic acid and ethyl alcohol, is a colorless liquid boiling at 165° C. It can be hydrolyzed to produce what is known as a hydrated silica sol or Silicon hydrochloride (1 mol per mol) is added to the formed choline solution at a temperature which is kept below 40Â° C. For hydrolysis, water (ice/ice water) is added to the solution while cooling, wherein the temperature is held within the range of -20Â° C. to -30Â° C. The solution containing the ortho silicic acid is subsequently neutralized by adding sodium hydroxide wherein cooling takes place to a temperature below 0Â° C. The pH neutralization amounts to about 1.3. Then achieved is that no organic silicon compounds are created which have an inherent toxicity, are absorbed in the stomach and enter the blood circulation. When researchers have studied osteoporosis in women, they found that eating a diet that includes 40 milligrams of silicon was linked with stronger bones than lower doses. In a watery environment silicon is initially present as ortho silicic acid which is quickly converted by polycondensation to polysilicic acid, which transposes into a colloidal solution and gels. Furthermore, orthosilicic acid and its small condensation compounds, such as its dimer (disilicic acid), linear and cyclic trimers (trisiloxanes), and tetramers (tetrasiloxanes) (Fig. The reaction mixture is maintained at a temperature between 125° and 250° C. High volume-time yields of the desired orthosilicic acid tetraalkoxyalkyl ester are provided. The biological preparation contains 3% by weight silicon in the form of ortho silicic acid, 70% by weight choline hydrochloride, the rest water and a pH of 2.7-3.0. A purification over active carbon is then performed, followed by filtering off the formed precipitate and the active carbon. If for instance an edible acid, such as malic acid, is added a preparation results which is very suitable for administering to horses. Bioavailability is precisely what makes it so much more valuable than any other silicon form. The invention relates to a process for the preparation of a high-purity, thermally stable catalyst carrier based on aluminosilicate with 0.5 to 50% by weight SiO 2 by mixing an aluminum compound with a silicic acid compound in an aqueous medium, and subsequently drying or calcining the product obtained. Water glass (sodium ortho silicate) is the usual source of ortho silicic acid, which however hydrolyses after oral administration to mammals and forms insoluble and non-absorbable gels through polycondensation. In contrast to this, it is known that ether alcohols can be used as stabilizing agents for chlorinated hydrocarbons whereby the chlorinated hydrocarbon is stabilized against attack by a metal. At 185° C., a total of 1 kg. Hence, the rate of ether alcohol addition must be such that the heat generated does not raise the reaction temperature above 250° C. Ether alcohols which are suitable for use in accordance with the invention are both the monoalkyl ethers which can be derived from ethylene glycol and those which can be derived from diethylene or triethylene glycol, the alkyl group amounting to from 1 to 8 and preferably 1 to 4 carbon atoms. A process for preparing an orthosilicic acid tetraester of a monoalkyl ether of an aliphatic glycol having 2 to 6 carbon atoms which comprises contacting silicon, iron silicide or ferrosilicon with a monoalkyl ether of an aliphatic glycol having 2 to 6 carbon atoms in the aliphatic chain in the presence of the corresponding orthosilicic acid tetraalkoxy alkyl ether at a temperature between 125 and 250° C. Dynamit Nobel Aktiengesellschaft (Troisdorf, DE), Click for automatic bibliography The first is obtained by a precipitation process and the second is presented as rock crystal. Privacy Policy Through use of a glucuronic acid buffer a preparation on a cream basis can be formed wherein the pH is less than 4, which creams are suitable for local cutaneous application. 2004-09-16. The reaction speed is improved when the silicon has a good ability to become wetted by the alcohol or alcoholates used in the process. Silicon is an essential trace element for plants, animals and humans. Usually recommended is a solution containing a stabilizing agent in which no hydrolysis can take place until after the addition of a hydrolyzing agent, such as water. In the same way as carbonic acid for compounds comprising carbon, ortho silicic acid is the most important metabolite for organic silicon compounds. The toxicity decreased markedly as the solution aged, to the point that after the solution turned to a gel it had no effects other than mechanical ones. More... Molecular Weight: 96.11 g/mol. It is often referred to as âsoluble silicaâ because Orthosilicic Acid is a dietary form of silicon (a mineral that is involved in the creation of collagen and bones).. It is also known that the surface of light metals is passivated when contacted with an ether alcohol. It, therefore, became desirable to provide a process for the preparation of such tetraalkoxyalkyl esters of orthosilicic acid whereby the desired ester could be obtained in a high volume-time yield. Another or additional type of stabilizing agent is an amino acid, such as proline and serine. All rights reserved. In a clinical study at the University of Antwerp, several leading silicon supplements were tested on volunteers for a week and 9 g of sodium. Preparations then result with a silicon content generally of 1% by weight, preferably of about 4% by weight, such as 8% by weight. Contents. Orthosilicic Acid (OSA) is a type of silicic acid that naturally occurs in water, seawater, and certain beverages (like beer). A usage of 0.5 ml of a 2% Si-solution per day for three weeks caused a fungal infection to disappear (3 patients), where treatment with ketonazols did not render any improvement. 424/724, 514/63, 514/970. Subcutaneous injections of orthosilicic acid solutions (around 1%) in mice were found to cause local inflammation and edema. Silicic acid only exists in two states, amorphous and crystalline. If desired, a further purification of the preparation can take place, for instance through absorption of contaminants on active carbon, optionally followed by filtration. generation, METHOD OF PREPARING ORTHOSILICIC ACID TETRAALKYL ESTERS, <- Previous Patent (Process for producin...). The ester that forms will then, however, be contaminated by compounds not further defined, which are caused by the impurities in the starting material. Moreover, it became desirable to provide such a process which could be carried out using readily available materials and did not require the assembly of an elaborate reaction vessel or system or the imposition of expensive processing parameters. Silicic acid in its amorphous form (SiO 3 ) Is white, unflavored, insoluble in water and does not form with some molecules of itself some cohesive plastic mass as with aluminum. The cream eventually contains 0.01-0.05% by weight silicon as ortho silicic acid. The reaction takes place at a temperature between 125° and 250° C., preferably 140° to 225° C. The reaction is very rapid under these conditions so that the volume-time yields are at least equal to and in many instances greater than the volume-time yields obtained for the corresponding preparation of orthosilicic acid tetramethyl esters as described in West German Pat. Tetrahydroxysilane. problems with connective tissues, arteriosclerosis, bone and tendon problems, gynaecology (fibroids, polycystic adenopathy); and. The bioavailability of silicon depends on the solubility or speciation of the compound concerned (Van Dyck et al., 1999). It was expected that the formation of any tetraalkoxyalkyl ether of orthosilicic acid would be obtained quite slowly. We also investigated whether orthosilicic acid promotes the urinary excretion of endogenous Al. Orthosilicic acid is a soluble form of silica present in mineral water. The fat phase is melted at 80Â° C., whereafter the water phase, also heated to 80Â° C., is admixed, followed by cooling. Dates: Modify . In addition, the safety of these â¦ The interaction of silicic acid with protein monolayers: Effect of pH and ionic strength of substrate. A silicon-comprising cream is prepared as follows. are separated from the reaction mixture, by filtration or centrifugation, for example, esters of greater purity are obtained upon distillation. Starting point for the preparation of the ortho silicic acid-comprising preparation is a solution containing the stabilizing agent, wherein an inert solvent can be used. With respect to the amount of hydrogen formed, the reaction corresponded to a volume-time yield of 770 grams per liter per hour. fr Composition renfermant de l'acide ortho-silicique stabilise, et composition biologique. It is a conjugate acid of a trihydrogensilicate(1-). The catalytic action of the alcoholate takes place only in solution. This spectrum is the same as the spectrum for choline. No. generation, Gelation stabilized water-soluble silicates, <- Previous Patent (Skin treatment compo...). For the achievement of the good volume-time yields it is important to stay within the temperature limits of the invention. When the ether alcohol feed is interrupted, the reaction soon ends as the ether alcohol still in the reactor is consumed. Ultimately, insoluble silicates are formed. If a solid carrier is added, for instance cattle feed, cattle feed pellets can be pressed therefrom which contain ortho silicic acid in stabilized form for administering silicon to cattle. A process for preparing an orthosilicic acid tetraester of a monoalkyl ether of an aliphatic glycol having 2 to 6 carbon atoms which comprises contacting silicon, iron silicide or ferrosilicon with a monoalkyl ether of an aliphatic glycol having 2 to 6 carbon atoms in the first alcohol chain in the presence of the corresponding orthosilicic acid tetraalkoxy alkyl ester present in an amount of 70 to â¦ Altâ¦ Supersmart - Orthosilicic Acid - Form of Silicon Found in Seawater - Bone & Joint Supplement - Minerals for Healthy Skin, Hair & Nails | Non-GMO & Gluten Free - 30 ml. Orthosilicic Acid Review . The amount of ether alcoholate in the reaction mixture is preferably between 2 and 5 weight percent with reference to the total amount of liquid. The procedure was similar to that of Example 2 except that the reaction was performed at 230° C. The volume-time yield was substantially higher than in Example 2, but the product purity fell below 90%. & Terms of Use. Silicon deficiency in animals leads to bone defects. A preparation comprising ortho silicic acid which is stabilized with a stabilizing agent and is substantially free of organic silicon compounds, preferably a nitrogen-containing stabilizing agent such as choline, to a method for preparing such a preparation, comprising: i) providing a solution containing a stabilizing agent; ii) dissolving an inorganic silicon compound in the solution containing the stabilizing agent; and iii) hydrolyzing the silicon compound to ortho silicic acid, â¦ The silicon or silicon alloy grain fineness is not to be too coarse, because the speed of the reaction diminishes as the grain size increases. ChEBI. The choline hydrochloride is treated with dry hydrochloric acid. As other monomeric silicon species, The reaction, however, will also take place with smaller amounts of alcoholate. Choline has been found very suitable, which is further recommended in that it provides the option of the stabilizing agent also forming the solution for the ortho silicic acid, and an inert solvent can therefore be omitted. Create . Monosilicic acid. The stabilization using a stabilizing agent preferably takes place with stabilizing agents containing a nitrogen atom with a free electron pair which forms a complex with the silanol groups of the ortho silicic acid. The present invention is based on the insight that if ortho silicic acid is formed in the presence of a stabilizing agent, polycondensation is inhibited and even avoided and, furthermore organic silicon compounds substantially do not occur. orthosilicic acid. This application is a 371 of PCT/NL95/00054, 00 ($26.73/Fl Oz) FREE Shipping. Moreover, the process does not provide the desired high volumne-time yields such as are obtained in the preparation of orthosilicic acid tetra (lower alkyl) esters. With respect to the hydrogen that was formed, the reaction corresponded to a volume-time yield of approximately 1145 g/liter/hour. 1. A two-liter glass vessel with stirrer, equipped with an insulated still, an infeed connection and a device for measuring the temperature in the liquid (thermocouple) was charged with 500 g of orthosilicic acid-2-methoxyethyl ester, which had previously been obtained by transesterification of orthosilicic acid tetramethyl ester with 2-methoxyethanol, plus 250 g of silicon (98% Si, 10μ diam.) This alkali metal ether alcoholate can be formed in situ by merely introducing into the reaction vessel, before charging the same with ether alcohol, the alkali metal itself. The pH of this preparation lies within the range 1-3. Orthosilic Acid (OSA) According to a 2016 article that expounded on the use of silicon for skin and hair health, orthosilicic acid (OSA) is believed to have the highest bioavailability. After the reaction vessel had been flooded with nitrogen, the mixture was heated with stirring to about 210° C., and first the sodium was reacted away by the addition of diethylene glycol monoethyl ether. If desired, the content of hydrolyzing agent, particularly water, can be reduced by removing the hydrolyzing agent, for instance through distillation, whereby a constant viscosity is achieved if use is made of choline as the stabilizer. All rights reserved. In order to achieve a result, processes of polycondensation of orthosilicic acid, ultrafiltration membrane concentration, and cryochemical vacuum sublimation are performed. © 2004-2021 FreePatentsOnline.com. A third aspect of the present invention relates to a biological preparation containing a preparation according to claims 1-7, and/or a preparation prepared according to claims 8-13, and a pharmacologically acceptable diluent. This invention is particularly directed to a process for the production of such orthosilicic acid tetraalkoxyalkyl esters which can be carried out at an exceptionally high volume-time yield, such as a volume-time yield equal to or better than the volume-time yields obtained in the preparation of orthosilicic acid tetraalkyl esters from simple alcohols. This invention relates particularly to the preparation of orthosilicic acid tetraesters of monoalkyl ethers of an aliphatic glycol, particularly to orthosilicic acid tetraalkoxyalkyl esters having 2 to 6 carbon atoms in the main chain and 1 to 4 carbon atoms in the chain of the monoalkyl ether. Quaternary ammonium compounds are preferably used, for instance tetra-alkyl compounds, wherein each alkyl group contains for instance 1-5 carbon atoms, in particular methyl and ethyl groups. Organic silicon compounds such as alcohol esters, such as ethyl ortho silicate and glycol ortho silicate, cannot be used in biological systems because of the poor solubility and the low resistance to hydrolysis, but above all because of the unacceptable toxicity. It will be apparent that all kinds of diluents can be used in order to obtain a preparation for biological application. Orthosilicic acid [Si(OH)4] is the major silicon species present in drinking water and other liquids, including beer, and is the most readily available source of silicon to man. The solution containing the stabilizing agent can initiate the hydrolysis immediately after addition of the inorganic silicon compound. The organic silicon preparation subject of this opinion is an aqueous solution of MMST at 4.1 mM, corresponding to 115 mg Si/L. At a vacuum of 0.5 Torr and a temperature of 230° to 240° C., 1030 g of orthosilicic acid tetraethyl diglycol ester was drawn off with a purity of 86%. At a vacuum of 0.1 Torr and a temperature of 158° C., 1280 g of orthosilicic acid tetra-2-ethoxyethyl ester was drawn off having a purity of 98.4%. The more carbon atoms the alkoxyalkyl ester has, the higher will be the preferred reaction temperature. Serine enhances uptake in the stomach and gives additional stability. Flavourings can be added if desired, for instance by dilution (1:30) in a 0.01 M citrate buffer (pH 3.5-3.8) and by adding a flavouring (raspberry and the like). Privacy Policy The second group includes, for example, methyldiglycol, ethyldiglycol and butyldiglycol. This liquid is suitable for oral and cutaneous administering. The in vitro effects of orthosilicic acid (0-50 microM) on collagen type 1 s â¦ When in such reaction mixture when in dissolved form it provides a catalytic function so that entering ether alcohol is readily formed, upon contact of the silicon-containing material into the orthosilicic acid tetraalkoxy ether. A first aspect of the present invention therefore relates to a preparation comprising ortho silicic acid which is stabilized with a stabilizing agent and is substantially free of organic silicon compounds. This element may therefore play an important role in bone metabolism. `Gmelins Handbuch der Anorganischen Chemie Silicium Part B`, 1959 Verlag Chemie GmbH. A very acceptable preparation contains 3-5% by weight of silicon, 70s by weight of choline hydrochloride and the rest water. The process can also be conducted under pressure say 1 to 10 atmospheres. FAB/MS with glycerol as liquid matrix provides a spectrum with a molecular cation at M/Z 104 (C+) and an MC+ adduction at M/Z243/245, typical for chloride isotropy. This process is complicated owing to the fact that a two-step process must be performed. Silicon is absorbed from the diet as orthosilicic acid and concentrations in plasma are 5-20 microM. It is of great importance herein that the stabilizing agent only forms a complex and does not enter into a reaction, particularly an esterifying reaction, with the ortho silicic acid. Biosil is orthosilicic acid, stabilized by choline chloride in this singular form, so it is immediately available for absorption. In the latter case it is recommendable to carry the end product in a secondary circuit. Element analysis produces 24Â±2% by weight chlorine and 9Â±1% by weight N. This points to a ratio of chloride to nitrogen of 1:1. Examples of the first-named group of compounds are 2-methoxyethanol, 2-ethoxyethanol and 2-propoxyethanol. It became particularly desirable to provide such a process which could be carried out in one step. NMR-SPECTRUM OF THE PREPARATION SHOWING CHOLINE/ALCOHOL GROUPS. There is also not enough scientific evidence to determine an appropriate dose when taking an orthosilicic acid supplement. A method for the preparation of a bioavailable silicic acid including extrudate, comprising: forming stabilized silicic acid, by hydrolysing a silicon compound into orthosilicic acid and/or oligomers thereof in the presence of a stabilizing agent, which is a quaternary ammonium compound consisting essentially of â¦ The procedure was similar to that of Example 2 except that the reaction was performed at 120° C. The volume-time yield dropped to 1/10 of that of Example 2. The physicochemical characteristics of the sols and nanopowders of SiO2 are determined using a set of methods. & Terms of Use. With respect to the amount of alcohol used and the amount of hydrogen formed, the reaction corresponded to a volume-time yield of about 750 grams per liter per hour. There therefore exists a need for a silicon-comprising preparation not possessing the above stated drawbacks, because silicon has a positive biological effect on nails, hair, skin, teeth, collagen, connective tissue, bones, encourages cell generation, stimulates the immune system against infections and toxins and inhibits degenerative (ageing)-processes. Biological preparations can be-manufactured from this prepared preparation for the purpose of administering ortho silicic acid to plants, animals and humans, whereby the bio-availability of silicon is greatly improved. the growth of children: children with recurrent infections with overload of the lymphatic system. Silicic acid (H4SiO4) Silicon tetrahydroxide. 250 g of silicon (98% Si, 10μ), 6 g of sodium and 500 g of orthosilicic acid-2-butoxyethanol previously obtained by the transesterification of orthosilicic acid tetramethyl ester with 2-butoxyethanol, were placed in the same apparatus as in Example 1. However, a corresponding amount of the ether alcoholate may be added to the mixture in solid form or in the form of a solution in the corresponding ether alcohol. Incorporated in -This solution is an inorganic silicon compound which hydrolysis under the influence of water to ortho silicic acid, which is immediately stabilized by the stabilizing agent that is present. iii) hydrolyzing the silicon compound to ortho silicic acid. As soon as more ether alcohol is added, a portion of the alcoholate dissolves and the reaction starts spontaneously. With respect to the alcohol put in and the hydrogen that was formed, the reaction corresponded to a volume-time yield of approximately 1150 grams per liter per hour. The reaction is catalyzed by small amounts of the corresponding ether alcoholate. Into such vessel there is also introduced silicon, iron silicide or ferrosilicon. Background: Silicon (Si) is a beneficial element that has been proven to influence plant responses including growth, development and metabolism in a hormetic manner. The process is particularly desirably carried out by including in the reaction mixture an alkali metal alcoholate corresponding to the ether alcohol to be introduced into the reaction mixture. Minimum, median uptake of Si from the ingested dose was 50.3% (range: 21.9-74.7%, n â¦ of 2-ethoxyethanol was fed in over a 30 minute period, while at the same time approximately 130 liters of H2 were formed. 250 g of silicon (98% Si, 10μ diam. When the ether alcohol is introduced into the reaction vessel containing the corresponding orthosilicic acid tetraalkoxyalkyl ester, silicon, iron silicide or ferrosilicon, an alkali metal, the corresponding alkali metal ether alcoholate is formed. Let's talk silica. Percent by Weight of Reactants Component Broad Preferred. A second aspect of the present invention relates to a method for preparing a preparation as according to claims 1-7, which comprises of: i) providing a solution containing a stabilizing agent; ii) dissolving an inorganic silicon compound in the solution containing the stabilizing agent; and. If it is desired to remove the ester continuously, the entire reaction may also be performed in vacuo. At a vacuum of 1 Torr and a temperature of 200° to 210° C., 1142 g of orthosilicic acid tetra-2-butoxyethyl ester was distilled out with a purity of 97.5%. © 2004-2021 FreePatentsOnline.com. After distillation under vacuum a preparation is obtained which contains 3% by weight of silicon, 70% by weight choline hydrochloride and the rest water. filed on Feb. 7, 1995. i) providing a solution containing a silicic acid stabilizing agent containing nitrogen selected from the group consisting of quaternary ammonium stabilizer and an amino acid stabilizer; ii) dissolving an inorganic silicon compound, which is capable of capable of forming ortho silicic acid, in the solution containing the stabilizing agent; and. Privacy Policy The grain size is therefore to be under 50 microns, insofar as possible. There is no recommended dietary allowance (RDA) for silicon. Neutralization can take place to a pH smaller than 4, in particular smaller than 3, in general to a pH lying in the range of 1-3, whereby any polycondensation of ortho silicic acid is substantially avoided. Orthosilicic acid. After the reaction chamber was flooded with nitrogen, the mixture was heated with stirring to about 200° C., and 2-butoxyethanol was slowly fed in until the sodium had reacted away. ";s:7:"keyword";s:29:"orthosilicic acid preparation";s:5:"links";s:662:"Vip Country Club, Excalibur Terraria Calamity, Teaching Without Frills Asking And Answering Questions, English Bulldogs For Sale On Craigslist, Señales De Que Tu Esposo Ya No Te Ama, ";s:7:"expired";i:-1;}