This deeply hurt Callie, as he basically told her their marriage was as poisonous as the toxic patient. At some point that day, Callie's patient was being operated on by Alex and Bailey without Callie even knowing about it. After Arizona realized she didn't want to go, she left Callie in an airport. Her mother briefly dated A couple of months into her internship, Leah started to make out with Alex in a supply closet for the last time before he left for Hopkins. Everyone was surprised, except for Alex. The same day, Callie noticed that Addison seemed to be interested in Alex. They then urged her to ask Callie to be her bridesmaid. Later, she decided she was going to go to the wedding and demand what she felt she deserved, but she immediately figured out that that was a bad idea.She agreed to cover Jo's patients for her while Jo went to April's wedding, but was over her hours, so Shane showed her how to modify her hours so it looked like she worked fewer hours than she had.
A bit later, Izzie asked George if he was really happy, but Callie heard the question and assured her that they were. Mark tried to resist by saying that the new Mark wasn't interested, but he eventually walked away. Jo told her what happened is that he's a guy. Then they went back to the case of After hearing that a resident was going to be fired, Leah began to stress eat. Erica started laughing, and so did Callie, but they gave each other somewhat of an awkward look.Some time later, Callie and Mark were having lunch. Mark was speechless. In the evening, she came back to tell Callie that was struggling with the fact that she was now number two, while she was used to being number one. Izzie did not welcome Callie and was upset that George had brought her to their house.After having spent the night at Meredith's, Callie went to the bathroom naked while Izzie and Meredith were there. Callie knew what he was about to say, and begged him not to say it as she was exhausted. During a surgery, Izzie made reference to Callie being rich. He told her he was available all day and night (in particular) to cheer her up. She comes across as somewhat cold and selfish, but in fact she cares a great deal about the people around her. He did continue to talk to her though, even though she initially didn't answer. Despite her efforts to assign him to Mark to keep him away from her, Callie ended up working with George when their patients refused to let go off a wedding dress because of a contest.
She told her patient she needed to learn to let go. Addison then told her her ring was beautiful, which made Callie happy. Just as he was giving her the goodbye speech he used on every other intern, they were interrupted by Callie, who was crying in the closet as they came in kissing. Even the usually icy Arizona initially brushed Callie off after kissing her in the bathroom at Arizona later found Callie and admitted she misjudged and asked her to dinner; Callie initially played hard to get, saying she would check her schedule, but gave in quickly, sticking out her arm to stop the elevator and accepting the date.After that, Callie started to work for Mercy West then comes back when both hospitals were merged. Izzie said that that didn't mean anything, that it was just a piece of paper. She quickly explained that it was simply easier to stay at the hospital since she was always there, and defended that she wasn't crazy. When Bailey asked her if she was going to come out to do her job, Callie asked why she should as Bailey was clearly doing it so much better. He said he only told Meredith and that he was disappointed that she didn't even give him the benefit of the doubt to believe him. Callie came to Erica's defense, naming some of Erica's qualities. Callie then thought that Meredith told George about this and went looking for her to kick her ass. While scrubbing in for a surgery on their patient, Cristina called Callie's work on their patient impressive. Callie found out that George was alone with his patient when the patient coded, and George told her that Meredith (his resident) was in the clinic. In the basement, Callie told George she washed her hands in the kitchen and not in the bathroom because Izzie and Meredith were staring at her in the bathroom, which made her feel uncomfortable.
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